Sitagliptin Impurity 53 HCl CAS 849832-76-4(free base)

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.849832-76-4(free base)
Molecular FormulaC6H9F3N4O
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Sitagliptin Impurity 53 HCl CAS 849832-76-4(free base) chemical structure

Description

The occurrence of Sitagliptin Impurity 53 HCl is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Sitagliptin Impurity 53 HCl (CAS 849832-76-4(free base)), a pharmacopoeial impurity reference standard (molecular formula C6H9F3N4OHCl, MW 246.62 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Sitagliptin Impurity 53 HCl (C6H9F3N4OHCl) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 246.62 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Sitagliptin Impurity 53 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC6H9F3N4O HCl
Molecular Weight246.62 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)2.0
Halogen ContentF/Cl-containing
Nitrogen Atoms4

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